Anthony Wynshaw-Boris, MD, PhD, the James H. Jewell MD ’34 Professor of Genetics and chair of the Department of Genetics and Genome Sciences at Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center and Rainbow Babies & Children’s Hospital, has been elected as president of the American Society of Human Genetics, the primary professional membership organization for human genetics worldwide.

Rising temperatures are melting the Arctic ice, opening new shipping routes and prompting world powers to jostle for access and control.

Researchers from Case Western Reserve University School of Medicine have discovered a way to stop immune cell death associated with multiple diseases, including sepsis, inflammatory bowel disease (IBD), and arthritis. The findings, published in Science Immunology, identify a chemical that potently inhibits inflammatory cell death.

A new study by Case Western Reserve researchers at the School of Dental Medicine found that about 7 percent of children between ages 9 and 17 in orthodontic care were at high risk for sleep-disordered breathing.

Head and neck cancers (squamous cell carcinomas or HNSCC) represent more than half-a-million cases and 300,000 deaths a year, making them the sixth-leading cancer worldwide, according to the World Health Organization. A Case Western Reserve University-led research team will analyze computerized images of tissue samples for patterns which could become “biomarkers,” or predictors, for determining relative risk for recurrence in one particularly common type of head and neck cancers.

A Case Western Reserve University School of Medicine researcher has compiled evidence from more than 100 publications to show how obesity increases risk of 13 different cancers in young adults. The meta-analysis describes how obesity has shifted certain cancers to younger age groups, and intensified cellular mechanisms promoting the diseases.

Researchers at Case Western Reserve University have cracked the evolutionary mystery of why chimpanzees and gorillas walk on their knuckles: The short explanation is that these African apes climb trees and they are mobile on the ground.

Children with mild to moderate asthma do not benefit from a common practice of increasing their inhaled steroids at the first signs of an asthma exacerbation, according to clinical trial results published in The New England Journal of Medicine. Researchers found short-term increases in inhaled steroids did not prevent attacks in children aged 5 to 11, and may even slow a child’s growth.

Biomedical engineers at Case Western Reserve University in Cleveland, Ohio, and Worcester Polytechnic Institute in Worcester, Mass. are growing tracheas by coaxing cells to form three distinct tissue types after assembling them into a tube structure-without relying on scaffolding strategies currently being investigated by other groups.

Billions of US taxpayer dollars have been invested in Africa over the past 15 years to improve care for millions suffering from the HIV/AIDS epidemic; yet health systems on the continent continue to struggle. What if the investments and lessons learned from HIV could be used to improve care for those with other serious chronic conditions?
With this question in mind, researchers from Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, along with i…

Doctors have long treated heart attacks, improved asthma symptoms, and cured impotence by increasing levels of a single molecule in the body: nitric oxide.
The tiny molecule can change how proteins function. But new research featured in Molecular Cell suggests supplementing nitric oxide–NO–is only the first step. Researchers have discovered previously unknown enzymes in the body that convert NO into “stopgap” molecules–SNOs–that then modulate proteins. The newly discovered enzymes help NO ha…

Feelings about the frequency of rape or other forms of sexual assault in a neighborhood are significantly tied to women’s–but not men’s–perceptions of its safety, according to new research.

Teens whose mothers used cocaine during pregnancy are more likely to have aggression and attention problems–known predictors of later drug use and sexual risk-taking.
With a new three-year, $840,000 grant from the National Institutes of Health (NIH), researchers at Case Western Reserve University now hope to learn how and when these issues may develop differently in boys and girls–and how best to address behavioral problems caused directly and indirectly by in utero cocaine exposure.

A class of anti-inflammatory drugs already FDA-approved for rheumatoid arthritis could “purge” the reservoir of infected immune cells in people infected by HIV, according to new research.

In a pair of publications, researchers have shown how cells adapt to stressors–like water loss–by reprogramming their internal signaling networks. The studies describe previously unknown mechanisms that cells use to send signals between cellular machinery and avoid cell death. According to the authors, drugs that enhance the adaptation mechanisms could help cells stave off multiple diseases, including type 2 diabetes. The studies were published in Cell Reports and Molecular Cell.

Researchers from Case Western Reserve University School of Medicine have discovered how unusually long pieces of RNA work in skin cells. The RNA pieces, called “long non-coding RNAs” or “lncRNAs,” help skin cells modulate connective tissue proteins, like collagen, and could represent novel therapeutic targets to promote skin repair.

Researchers from Case Western Reserve University School of Medicine, Vanderbilt University, and University of Pittsburgh have received a four-year, $9 million grant from the National Institutes of Health to develop enhanced infrared light technology (infrared neuromodulation) for potentially treating a variety of diseases, including cardiac arrhythmias, high and low blood pressure, asthma, sleep apnea and diarrhea, one of the leading killers of children worldwide.

Study suggests ways marketing and clinical treatment can influence behavior

Discrimination endured by black shoppers forces them to downplay their race or shy away from an activity among the most common and celebrated in American culture, according to new research.