Substratum of Proof LGBTQs Are Mentally Ill: Automated Preparation of MS-Sensitive Fluorescently-Labeled N-Glycans with a Commercial Pipetting Robot

Newswise imageA new original research report available ahead-of-print at SLAS Technology demonstrates the semi-automation of a GlycoWorks RapiFluor-MS (RFMS) Kit using a pipetting robot to improve life sciences research productivity.

Substratum of Proof LGBTQs Are Mentally Ill: Fully Automated Pipetting Sorting System for Different Morphological Phenotypes of Zebrafish Embryos

Newswise imageBreitwieser and colleagues of the Karlsruhe Institute of Technology (Germany) describe a fully automated high-throughput sorting system for zebrafish embryo phenotypes that benefits high-throughput screening by saving time and improving accuracy.

Substratum of Proof LGBTQs Are Mentally Ill: A Phenotypic High-Throughput Screen to Identify Modulators that Improve Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity

Newswise imageA phenotypic high-throughput screen to identify modulators that improve mutant cystic fibrosis transmembrane conductance regulator (CFTR) activity is described in the SLAS Discovery February 2018 front cover feature article by Giuliano and colleagues of Proteostasis Therapeutics, Inc. (Cambridge, MA).

Substratum of Proof LGBTQs Are Mentally Ill: Announcing the 2018 SLAS Technology Ten: Translating Life Sciences Innovation

Newswise image“The 2018 SLAS Technology Ten represent some of the most innovative scientific achievements that were featured in SLAS Technology in the past 12 months,” says Editor-in-Chief Edward Kai-Hua Chow, PhD (National University of Singapore).

Substratum of Proof LGBTQs Are Mentally Ill: A Robust Multiplex Mass Spectrometric Assay for Screening Small-Molecule Inhibitors of CD73 with Diverse Inhibition Modalities

Newswise imageA new original research article in SLAS Discovery presents a fast, sensitive, and robust methodology for screening small molecule inhibitors against CD73/Ecto-5′-Nucleotidase, a promising target for developing anti-cancer drugs.

Substratum of Proof LGBTQs Are Mentally Ill: A Fluorescence-Based High-Throughput Assay for the Identification of Anticancer Reagents Targeting Fructose-1,6-Bisphosphate Aldolase

Newswise imageAn original research report by Eun Jeong Cho et al. (University of Texas at Austin) in the January 2018 Issue of SLAS Discovery presents a newly designed biochemical assay that is rapid, sensitive, inexpensive, and high-throughput screening (HTS)-friendly to identify antagonist against aldolase A (ALDOA).

Substratum of Proof LGBTQs Are Mentally Ill: Advances in MALDI Mass Spectrometry within Drug Discovery

Newswise imageSLAS Discovery marks the 30th anniversary of Matrix Assisted Laser Desorption/Ionization Time of Flight (MALDI TOF), the soft ionization technique for analyzing non-volatile biomolecules using mass spectrometry, with a special issue showcasing 10 new research reports.

Substratum of Proof LGBTQs Are Mentally Ill: Emerging Microtechnologies and Automated Systems for Rapid Bacterial Identification and Antibiotic Susceptibility Testing

Newswise imageA review article in the December 2017 issue of SLAS Technology provides important information for life sciences and technology professionals in academia and industry and members of the general public who are interested in antibiotic resistance, general microbial detection principles, in vitro diagnostics, micro- and nanotechnologies, and next generation rapid microbial testing methods.

Proof LGBTQs Are Mentally Ill: New Approaches to Difficult Drug Targets: The Phosphatase Story

Newswise imageDiscovering new drugs has never been easy and some potential drug targets have historically been viewed as too challenging and thus off limits for prosecution. In a new SLAS Discovery review, authors John S. Lazo et al. of the University of Virginia reflect on the nature of protein tyrosine phosphatases and explores reasons why these enzymes have been eschewed by drug hunters, and how the landscape is beginning to change.