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New research has begun to identify the circumstances by examining relationships between early age of first intoxication (less than 15 years), drinking in different contexts such as one's own home, at friends' homes, or outdoor settings, and problems that arise in those contexts.

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Active, middle-aged men able to complete more than 40 push-ups had a significantly lower risk of cardiovascular disease (CVD) outcomes — including diagnoses of coronary artery disease and major events such as heart failure — during 10 years of follow-up compared with those who were able to do less than 10 push-ups during the baseline exam.

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A genetic variant found only in people of African descent significantly increases a smoker's preference for cigarettes containing menthol, a flavor additive. The variant of the MRGPRX4 gene is five to eight times more frequent among smokers who use menthol cigarettes than other smokers. The multi-ethnic study is the first to look across all genes to identify genetic vulnerability to menthol cigarettes.

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Researchers have developed a promising drug that has proven to significantly increase muscle size, strength and metabolic state in aged mice, according to a new study.

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Some of the damaging cell effects linked to aging could be prevented by manipulating tiny parts of cells, a study shows.

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Researchers from Cardiff University have established a link between a genetic mutation and developmental movement impairments in autism.

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Multiple sclerosis (MS) and other inflammatory autoimmune diseases are characterized by localized inflammation in various tissues, including the brain. Using a mouse model of MS, a team has identified a major regulator of Th17 cell-associated pathogenic inflammatory processes. The protein, Satb1, enhances the expression of genes promoting inflammation and suppresses genes needed to prevent autoimmunity. By targeting this protein, novel therapies may be able to attenuate inflammatory autoimmune diseases.

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Acute myeloid leukemia (AML) is the most common form of acute leukemia. It is characterized by an increase of malignant myeloid progenitor cells at the expense of mature blood cells. Only twenty-five percent of all AML patients survive five years beyond the initial diagnosis. Therefore there is an urgent need to deepen the knowledge about this form of blood cancer and to develop new therapeutic approaches.

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The neural 'time windows' in certain small brain areas contribute to the complex cognitive symptoms of autism, new research suggests. In a brain imaging study of adults, the severity of autistic symptoms was linked to how long these brain areas stored information. The differences in neural timescales may underlie features of autism like hypersensitivity and could be useful as a future diagnostic tool.

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Even as hospitals try to cut back on prescribing powerful but risky antibiotics called fluoroquinolones, a new study shows that many patients still head home with prescriptions for the drugs -- increasing their risk of everything from 'superbug' infections to torn tendons. In fact, the hospitals that are actively trying to reduce inpatient fluoroquinolone use were twice as likely to discharge patients with a new prescription for one of them.

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A group of more than 60 leading international neuroscientists are asking for balance when reporting on sports-related injury chronic traumatic encephalopathy (CTE).

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By examining how mammary cells respond in a stiffness-changing hydrogel, researchers discovered that several pathways work together to signal breast cells to turn cancerous. The work could inspire new approaches to treating patients and inhibiting tumor growth.

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UCLA researchers have found that people involved in electric scooter accidents are sometimes injured badly enough -- from fractures, dislocated joints and head injuries -- to require treatment in an emergency department.

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Vivid dreams involving drinking and drug use are common among individuals in recovery. A study finds these relapse dreams are more common in those with more severe clinical histories of alcohol and other drug problems.

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What makes us human, and where does this mysterious property of 'humanness' come from? Humans are genetically similar to chimpanzees and bonobos, yet there exist obvious behavioral and cognitive differences. Now, researchers have developed a strategy to more easily study the early development of human neurons compared with the neurons of nonhuman primates.

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Researchers have discovered how overactive DNA repair systems can lead to retinal damage and blindness in mice. A DNA repair enzyme called Aag glycosylase becomes hyperactive, provoking an inflammatory response that produces necrosis, leading to severe tissue damage.

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In a new study, researchers report that hearing impairment is associated with accelerated cognitive decline with age, though the impact of mild hearing loss may be lessened by higher education.

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By zeroing in on humans' gait, body symmetry and foot placement, researchers are teaching self-driving cars to recognize and predict pedestrian movements with greater precision than current technologies.

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The bacterial pathogen Helicobacter pylori owes its worldwide distribution to its genetic adaptability. Microbiologists have identified an enzyme that plays a vital role in the flexible control of global gene expression in the species.

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Induced pluripotent stem cells, the workhorse of many regenerative medicine projects, start out as differentiated cells that are reprogrammed to pluripotent stem cells by exposure to a complex set of genetic cocktails.