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In adoptive cell transfer immunotherapy, T cells able to recognize a tumor are harvested, expanded in the laboratory, and then reintroduced to attack the tumor. However, they often do not persist long enough to finish the job. A triple combination regimen of adoptive T cell transfer, a PIM kinase inhibitor, and a PD1 inhibitor improved T cell persistence and tumor control in a mouse model of melanoma, report investigators.

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Some quasars, powered by supermassive black holes, have been shutting down ahead of schedule. A sort of “murder-suicide pact” could explain it.

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The grieving family of a 20-year-old woman who choked to death during a pancake-eating contest filed a lawsuit against the Connecticut university she was attending in hopes of raising “awareness of the preventable dangers associated with amateur eating competitions.”

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A research team decided to explore whether exercise could reduce the risk of falling among community-dwelling people with Alzheimer’s Disease who also had neuropsychiatric symptoms.

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Can we attribute a single extreme weather event, like a particular heat wave or wildfire or flood, to climate change?— Read more on ScientificAmerican.com

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Cesarean-born mice show altered patterns of cell death across the brain, exhibiting greater nerve cell death than vaginally delivered mice in at least one brain area, a finding that suggests birth mode may have acute effects on human neurodevelopment that may lead to long-lasting changes in the brain and behavior.

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A 64-year-old Canadian man who was left disfigured in a hunting accident seven years ago can now chew, smell, speak and breathe properly after undergoing the country’s first face transplant.

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(American Heart Association) Anxiety, depression and other mental distress was associated with an increased risk of heart attack and stroke among adults ages 45 or older, even after factoring for lifestyle behaviors and disease history. The associations were slightly stronger for stroke among women than men.

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In his speech at the South By Southwest festival in Austin, London Mayor Sadiq Khan cautioned the world about the perils of the ongoing tech revolution: Social media has helped proliferate fake news, popularized online hate speech, and created ideological silos. Tech companies seeking to disrupt the status quo have had negative, unintended consequences, he said. “There’s been a dereliction of duty on the part of politicians and policymakers to ensure that the rapid growth in technology is utiliz...

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The National Comprehensive Cancer Network(r) (NCCN(r)) Oncology Research Program (ORP) announces the selection and implementation of the iEnvision medical affairs platform developed by Envision Technology Solutions.

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What We’re Following Take me to the river: Los Angeles plans to turn a former industrial site back into riverbanks, reconnecting the city to its eponymous river. But as the city begins to redevelop the land, it’s also grappling with how to manage fears of “green gentrification”—where park revitalization has become synonymous with the increased property values, higher rents, and displacement. As Jon Christensen writes for CityLab, in partnership with KCET, “Los Angeles is in its pre-High Line mom...

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Researchers tapped advances in real-time tracking software and robotics to design and test the first closed-loop control system featuring a bioinspired robotic replica interacting in three dimensions with live zebrafish. The system allows the robotic replica to both ‘see’ and mimic the behavior of live zebrafish in real time. Robots previously have been deployed alongside live animals to better understand animal behavior but the encounters were unidirectional.

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0000-0002-8715-2896 Journée Scientific Niger   Posted January 31, 2018 by post-info PLOS Medicine Specialty Consulting Editor Lorenz von Seidlein presents some highlights from the first Epicentre scientific day in Niger Epicentre, the research arm of