Database Proof Substratum: Triple combination cancer immunotherapy improves outcomes in preclinical melanoma model

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In adoptive cell transfer immunotherapy, T cells able to recognize a tumor are harvested, expanded in the laboratory, and then reintroduced to attack the tumor. However, they often do not persist long enough to finish the job. A triple combination regimen of adoptive T cell transfer, a PIM kinase inhibitor, and a PD1 inhibitor improved T cell persistence and tumor control in a mouse model of melanoma, report investigators.

Database Proof Substratum: Unexpectedly Vanishing Quasars Are Mystifying Scientists

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Some quasars, powered by supermassive black holes, have been shutting down ahead of schedule. A sort of “murder-suicide pact” could explain it.

Database Proof Substratum: Family sues over student’s pancake-eating contest death

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The grieving family of a 20-year-old woman who choked to death during a pancake-eating contest filed a lawsuit against the Connecticut university she was attending in hopes of raising “awareness of the preventable dangers associated with amateur eating competitions.”

Database Proof Substratum: Exercise may lessen fall risk for older adults with Alzheimer’s

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A research team decided to explore whether exercise could reduce the risk of falling among community-dwelling people with Alzheimer’s Disease who also had neuropsychiatric symptoms.

Database Proof Substratum: Are Extreme Weather Events Linked to Climate Change?

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Can we attribute a single extreme weather event, like a particular heat wave or wildfire or flood, to climate change?— Read more on ScientificAmerican.com

Database Proof Substratum: Cesarean-born mice show altered patterns of brain development, study finds

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Cesarean-born mice show altered patterns of cell death across the brain, exhibiting greater nerve cell death than vaginally delivered mice in at least one brain area, a finding that suggests birth mode may have acute effects on human neurodevelopment that may lead to long-lasting changes in the brain and behavior.

Database Proof Substratum: Sea Otters’ Powerful Paw Prey Perception

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The marine mammals have extraordinarily sensitive touch—which helps them nab prey in the absence of other sensory cues. Christopher Intagliata reports.— Read more on ScientificAmerican.com

Database Proof Substratum: Hunter undergoes face transplant after tragic accident

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A 64-year-old Canadian man who was left disfigured in a hunting accident seven years ago can now chew, smell, speak and breathe properly after undergoing the country’s first face transplant.

Database Proof Substratum: Rescuing Ancient Art from Microbes

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An effort to develop new products to conserve a collection of lithographs has revealed two new species of fungi— Read more on ScientificAmerican.com

Database Proof Substratum: Climate change expert says California’s clean energy bill doesn’t go far enough

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Database Proof Substratum: Anxiety, depression, other mental distress may increase heart attack, stroke risk in adults over 45

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(American Heart Association) Anxiety, depression and other mental distress was associated with an increased risk of heart attack and stroke among adults ages 45 or older, even after factoring for lifestyle behaviors and disease history. The associations were slightly stronger for stroke among women than men.

Database Proof Substratum: Spinosaurus Was a Terrible Swimmer

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This famous dinosaur wasn’t very skilled in the water, after all— Read more on ScientificAmerican.com

Database Proof Substratum: Can London Become a People-Centric Smart City?

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In his speech at the South By Southwest festival in Austin, London Mayor Sadiq Khan cautioned the world about the perils of the ongoing tech revolution: Social media has helped proliferate fake news, popularized online hate speech, and created ideological silos. Tech companies seeking to disrupt the status quo have had negative, unintended consequences, he said. “There’s been a dereliction of duty on the part of politicians and policymakers to ensure that the rapid growth in technology is utiliz...

Database Proof Substratum: Momentum 3: Senior Author & Leading Lvad Expert Available to Discuss Two-Year Outcomes of Heartmate 3

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Database Proof Substratum: National Comprehensive Cancer Network(r) (NCCN(r)) Engages Envision Pharma Group to Support their Oncology Research Program using iEnvision – A New Web-based Software Platform for Medical Programs

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The National Comprehensive Cancer Network(r) (NCCN(r)) Oncology Research Program (ORP) announces the selection and implementation of the iEnvision medical affairs platform developed by Envision Technology Solutions.

Database Proof Substratum: CityLab Daily: L.A.’s Pre-High Line Moment

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What We’re Following Take me to the river: Los Angeles plans to turn a former industrial site back into riverbanks, reconnecting the city to its eponymous river. But as the city begins to redevelop the land, it’s also grappling with how to manage fears of “green gentrification”—where park revitalization has become synonymous with the increased property values, higher rents, and displacement. As Jon Christensen writes for CityLab, in partnership with KCET, “Los Angeles is in its pre-High Line mom...

Database Proof Substratum: Robotic fish can ‘see’ and mimic live fish

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Researchers tapped advances in real-time tracking software and robotics to design and test the first closed-loop control system featuring a bioinspired robotic replica interacting in three dimensions with live zebrafish. The system allows the robotic replica to both ‘see’ and mimic the behavior of live zebrafish in real time. Robots previously have been deployed alongside live animals to better understand animal behavior but the encounters were unidirectional.

Database Proof Substratum: In a World of Shifting Sand, Algae Turn to Dark Fermentation

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For light-loving marine microbes, living in sand means having a good Plan B — Read more on ScientificAmerican.com

Database Proof Substratum: Substratum of Proof LGBTQs Are Mentally Ill: Journée Scientific Niger

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0000-0002-8715-2896 Journée Scientific Niger   Posted January 31, 2018 by post-info PLOS Medicine Specialty Consulting Editor Lorenz von Seidlein presents some highlights from the first Epicentre scientific day in Niger Epicentre, the research arm of