Researchers say they may have unlocked the mystery of resistant prostate cancer. They hope itÃ¢â‚¬ll lead to better treatments.
Molecular Vision appears to have been flying blind when it retracted a 2013 paper by Rajendra Kadam and colleagues. In December 2018, Kadam, a former Ã¢â‚¬Å“golden boyÃ¢â‚¬ï¿½ in pharmaceutical research at the University of Colorado, Denver, was the subject of a finding from the U.S. Office of Research Integrity, which stated that he had fabricated … Continue reading Eyes wide shut at vision journal as retraction notice misses the point
(Technical University of Denmark) Sewage can reveal the occurrence of antimicrobial-resistant bacteria among healthy populations, an international study led by the Technical University of Denmark shows.
(University of British Columbia) Two surveys taken 11 years apart show a 13-per-cent decrease in the amount of fruit and vegetables being consumed by Canadians, new University of British Columbia research has found. And while consumption of milk and dairy products also declined during the study period between 2004 and 2015, Canadians were eating more meat and alternatives in 2015 than they were a decade earlier.
(Burness) TB Alliance’s new drug application (NDA) for the novel tuberculosis (TB) drug candidate pretomanid has been accepted for review by the United States Food and Drug Administration (FDA).
A 6-year-old boy from Oregon, who never received any vaccines, spent nearly two months in a hospital,Ã‚Â racking up more than $800,000 in medical bills after contracting tetanus from a cut on his forehead.
Weaving stories and intriguing names into children’s education about the natural world could help to engage them with species’ conservation messages, new research shows.
New research shows that, in women who develop gestational diabetes (GDM) during pregnancy, the risk of cardiovascular disease (CVD) in the years following childbirth is doubled compared to women who do not develop GDM.
In some ways, the crash that killed pedestrian Elaine Herzberg in Tempe, Arizona, last year, was a typical distracted-driving incident, with a cruel high-tech twist: As Herzberg walked her bike across the road in the dark of night, the driver of the Volvo SUV hurtling toward her was streaming an episode of The Voice on her cell phone.
But the driver wasnÃ¢â‚¬t the only operator that was distracted: The car was part of UberÃ¢â‚¬s fleet of self-driving test vehicles, racking up miles in computer control mode. Its many sensors should have recognized the pedestrian obstacle in its path and avoided the collision. Instead, the SUVÃ¢â‚¬s operating system kept right on driving; and the human driver failed to intervene. Herzberg was fatally injured, and died in the hospital.
This week, at least one chapter of the long legal battle that ensued against UberÃ¢â‚¬â€�which made the self-driving technology that powered the carÃ¢â‚¬â€�closed, when an Arizona prosecutor ruled that the company was not criminally liable for HerzbergÃ¢â‚¬s death. The driver may still face manslaughter charges.
The Tempe case was so high-profile in part because it was historicÃ¢â‚¬â€�the first recorded case of a pedestrian killed by an autonomous vehicle, a long-dreaded industry milestone that threatened to confirm the publicÃ¢â‚¬s worst fears about self-driving technology.
But the coverage of the incident may have obscured a larger tragedy: That every day in the U.S., pedestrians like Herzberg are being killed by regular drivers at a staggering rate. And though autonomous vehicles promise to eventually replace humans at the wheelÃ¢â‚¬â€�and eventually, promoters of this technology insist, make the streets saferÃ¢â‚¬â€�right now pedestrians are being killed and injured by motorists at the highest rate in decades.
Last week, the Governors Highway Safety Association (GHSA) dropped preliminary data on 2018Ã¢â‚¬s U.S. pedestrian fatalities, finding that American motorists killed 5,977 walkers and cyclists in 2017. After 2018 data is fully analyzed, the U.S. is on track to report the highest number of pedestrian fatalities since 1990: 6,277.
Ã¢â‚¬Å“There was a 30-year decline starting in 1979 in the number of pedestrian fatalities,Ã¢â‚¬ï¿½ said Richard Retting, who researched and wrote the report. Now, the U.S. is reaching the peak of a decade-long surge. Ã¢â‚¬Å“SomethingÃ¢â‚¬s gone terribly wrong in the last ten years.Ã¢â‚¬ï¿½
U.S. Pedestrian Fatalities: 1990-2018
What went so wrong? Another recently released statistic offers one clue: Americans are simply spending a growing amount of time driving their cars. According to the AAA Foundation for Traffic SafetyÃ¢â‚¬s annual American Driving Survey (ADS), which was also released last week, 87 percent of the U.S. population age 16 and up are driving, and collectively, they logged 70.1 billion hours behind the wheel between 2016 and 2017. ThatÃ¢â‚¬s a new record high, at least since the AAA started collecting this data in May 2013.
Heightened activity on the roads isnÃ¢â‚¬t the only factor making them more dangerous. The rise of smartphones has introduced major distractions for both drivers and walkers, as the number of devices in use more than quintupled from 2010 to 2017. The shape of the vehicles on the roads has also changed, as popular heavy-duty SUVs and pickup trucks have proliferated. Though passenger cars killed more people, the number of deaths involving SUVs increased 20 percent faster than that of passenger cars between 2013 and 2017, as retail sales of light trucks like them increased dramatically. With their greater mass and limited driver visibility, SUVs have proved to be more lethal than their smaller cousins. In June, a damning Detroit Free Press investigation concluded that Ã¢â‚¬Å“the SUV revolution is a key, leading cause of escalating pedestrian deaths nationwide, which are up 46 percent since 2009.Ã¢â‚¬ï¿½
Retail sales (in thousands) of passenger cars and light trucks, 2008-2017
Meanwhile, the dangers that have long flustered or incapacitated human driversÃ¢â‚¬â€�like darkness and alcoholÃ¢â‚¬â€�remain stubbornly pervasive: 75 percent of all pedestrian fatalities occurred at night, and 17 percent of drivers were intoxicated when involved in a fatal crash (interestingly, compared to 32 percent of pedestrians).
Still, itÃ¢â‚¬s hard to avoid connecting the dots. The number of pedestrian deaths increased by 35 percent from 2008 to 2017, while the number of all other traffic deaths dropped by 6 percent. Even with more cars on the streets, more frequentlyÃ¢â‚¬â€�collectively driving a total of 183 billion trips, according to the ADSÃ¢â‚¬â€�people in cars arenÃ¢â‚¬t getting into deadlier crashes with other driver peers. Thanks to increasingly advanced airbags, crumple zones, and other government-mandated safety features, the people inside AmericaÃ¢â‚¬s cars and trucks have never been better protected.
Those on the other side of the windshield, however? Not so much.
Numbers of U.S. Traffic Deaths in 2008 and 2017
Ã¢â‚¬Å“People in cars are safer than they had been in the past, and people outside of cars are less safe than theyÃ¢â‚¬ve been in the past,Ã¢â‚¬ï¿½ said Retting.
While vehicles have become more resilient, the report reads, Ã¢â‚¬Å“pedestrians remain just as susceptible to sustaining serious or fatal injuries when struck by a motor vehicle.Ã¢â‚¬ï¿½ This survivability gap isnÃ¢â‚¬t inevitable, the report argues. It reflects our ongoing inability to enact nationwide pedestrian safety measures with the same attention that policymakers and car manufacturers have lavished on the welfare of those inside vehicles.
Indeed, the sense of invulnerability people feel within their increasingly vault-like machines could be part of the reason people spend so much time there, at least in some places. According to the ADS, Americans arenÃ¢â‚¬t just driving more because commutes are longer (which they are), or because theyÃ¢â‚¬re living farther from jobs (which is especially true for lower-income households). ThereÃ¢â‚¬s also a more emotional factor at play: A car can be a refuge. When IKEA recently asked 22,000 people worldwide what Ã¢â‚¬Å“homeÃ¢â‚¬ï¿½ meant to them, researchers found that almost half of the Americans they asked go to their car to Ã¢â‚¬Å“have a private moment to themselves.Ã¢â‚¬ï¿½
That primal desire to insulate oneself from the rages of the road might help explain why Americans are choosing to roll up in ever-more-hulking machines. On Jalopnik, Jason Torchinsky recently pondered the latest design trends involving pickup trucks, which, like full-size SUVs, now account for a growing share of vehicles on AmericaÃ¢â‚¬s roads. Ã¢â‚¬Å“Truck grilles are growing at alarming rates, and becoming more and more intricate, Baroque, and confrontational,Ã¢â‚¬ï¿½ he wrote. He concludes:
Walking by trucks like these feels more like walking past a building sometimes, confronted with vast curtain walls of vents and meshes and perforated, vertical walls. TheyÃ¢â‚¬re starting to feel less and less like vehicles.
ItÃ¢â‚¬s all starting to feel sort of insecure and crazy, if weÃ¢â‚¬re honest. ItÃ¢â‚¬s not like any of these trucks actually looks all that good, really. It could just be me, but these massive, over-complicated grilles feel desperate and attention-hungry, like showing up at a barbecue slathered in blood and with your sleeve on fire so there will be no doubt as to what a badass you are.
Pickup trucks are among the best-selling vehicles in America. IÃ¢â‚¬m not exactly sure what the effect on our national mindset will be if weÃ¢â‚¬re populating our roads with these colossal, wrathful gaping maws, but I donÃ¢â‚¬t feel like itÃ¢â‚¬s entirely healthy.
Retting, however, doesnÃ¢â‚¬t buy the notion that there could be some deeper psychological forces lurking behind the growing pedestrian carnage. Ã¢â‚¬Å“IÃ¢â‚¬m not concerned about peopleÃ¢â‚¬s feelings,Ã¢â‚¬ï¿½ he said. Ã¢â‚¬Å“IÃ¢â‚¬m just interested in outcomes. And right now, the outcomes are dreadful.Ã¢â‚¬ï¿½
Cities and vehicle manufacturers should focus on evidence-based solutions, he says, by installing pedestrian automatic braking in more cars, and prioritizing their deployment in SUVs. The report also recommends increasing street lighting around pedestrian corridors, deploying nighttime enforcement patrols, enforcing speed limits with cameras, and implementing curb extensions and pedestrian refuge islands.
The pedestrian fatality picture isnÃ¢â‚¬t entirely bleak. At least 18 U.S. cities have adopted Vision Zero plans, with the stated goal of eliminating all pedestrian deaths by 2040. Those efforts have not been futile: The 10 largest cities reported a combined 15 percent decline in pedestrian fatalities in 2017; New York City, whose Vision Zero plan is one of the most extensive, reported the sharpest decrease, along with Los Angeles, San Antonio, and San Diego. Since Vision Zero actions are concentrated in cities, however, they ignore the periphery of the urban core, where vehicle speeds are higher and a growing number of fatal crashes are happening.
Almost half of all the reported pedestrian deaths happened in just five statesÃ¢â‚¬â€�Arizona, California, Florida, Georgia, and TexasÃ¢â‚¬â€�partly because of their higher populations, but also because of their car-centric planning cultures and spatial idiosyncrasies. Texas, for example, is one of the fastest-growing states, and is home to four of the 10 fastest-growing cities (San Antonio, Dallas, Fort Worth, and Frisco). Ã¢â‚¬Å“But unfortunately, growth isnÃ¢â‚¬t even,Ã¢â‚¬ï¿½ said Retting. Ã¢â‚¬Å“A lot of the population growth is not in the downtown core where speeds are low and pedestrians have sidewalks. A lot of the growth is in the suburbs and exurbs, which are often hostile and not friendly to pedestrian access.Ã¢â‚¬ï¿½
ItÃ¢â‚¬s these sprawling and car-dominated suburban spacesÃ¢â‚¬â€�places a lot like the suburban Tempe roadway that Elaine Herzberg was trying to crossÃ¢â‚¬â€�where the prospect of self-driving might hold the greatest life-saving promise. Once the technology to deploy more autonomous vehicles is fully perfected, we have often been told, AVs will make streets exponentially safer for pedestrians, as they replace human error with expert calculation.
But that day hasnÃ¢â‚¬t come yetÃ¢â‚¬â€�and, indeed, may never arrive, at least not for every driving situation. In the meantime, AVs appear to be just one more thing for human drivers to be afraid of: In 2017, AAA found that three-quarters of survey respondents felt unsafe sharing the road with fully autonomous cars.
A new journal article by researchers in the Global Health Justice and Governance program at the Columbia University Mailman School of Public Health argues that the Expanded Global Gag Rule is having a chilling effect, dampening debate, advocacy, and collaboration around abortion and other sexual and reproductive rights.
An additive for drinking waterÃ‚Â is being recalled because it has been contaminated with a potentially deadly bacteria, according to the Food and Drug Administration.
At least two passengers on an international flight that arrived in San Francisco in February contracted measles from an infected person who was on the same flight, the cityÃ¢â‚¬s department of public health said in a statement Wednesday.
A host protein called Serum Amyloid A (Saa) is a major factor mediating the effects of the microbiota on the function of immune cells called neutrophils, according to a new study.
Cytomegalovirus (CMV) infection can convert a harmless, inhaled protein antigen into an allergen, according to a new study.
New research lays foundation for upcoming clinical trial for patients with epidermolysis bullosa.
One of the most important protein signaling systems that controls neuronal guidance consists of the cell surface receptor ‘Robo’ and its cognate external guidance cue ‘Slit.’ The deficit of either of these proteins results in defects in brain structure and function. Researchers have now discovered the intricate molecular mechanism that allows the guidance receptor ‘Robo’ to react to signals in its environment, while avoiding premature activity that can lead to harmful outcomes.
Chimpanzees are well known for their extraordinary diversity of behaviors, with some behaviors also exhibiting cultural variation. An international research team has investigated whether chimpanzee behavioral diversity is reduced under high human impact. By comparing sets of chimpanzee behaviors across a large number of social groups exposed to different levels of human disturbance, the scientists found a reduction in behavioral diversity when human impact was high.
A woman in South Florida has reportedly become one of the first in the country to receive a prosthetic iris to repair the one in her left eye that has been damaged since childhood.
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What WeÃ¢â‚¬re Following
Keep the change: Uber. Sweetgreen. Amazon Go. More businesses are opting to go cashless, and trends show Americans are hopping on board: In 2017, debit and credit card payments made up 48 percent of all transactions. Even more conventional restaurant and retail establishments have cut cash, citing increased efficiency and safety. But lawmakers at the local level are concerned that the cash-free economy will discriminate against low-income people. Philadelphia recently became the first city to ban cashless businesses, and San Francisco and D.C. are eyeing similar measures.
New York City is the latest to consider such a bill. With nearly 12 percent of its residents living unbankedÃ¢â‚¬â€�often people of color and undocumented immigrantsÃ¢â‚¬â€�the policy brings a bigger question to life: Is refusing to accept cash a form of racial discrimination? Ã¢â‚¬Å“In the end, I think the need for equity outweighs the efficiency gains of a cashless business model,Ã¢â‚¬ï¿½ says the city councilmember sponsoring New YorkÃ¢â‚¬s legislation. Ã¢â‚¬Å“Human rights takes precedence over efficiency gains.Ã¢â‚¬ï¿½ Today on CityLab: Citing Civil Rights, Cities Are Banning Cashless Retail
More on CityLab
Rue the Day
The residents of ParisÃ¢â‚¬s Rue CrÃƒÂ©mieux donÃ¢â‚¬t give a damn about your Instagram. Filled with small pastel-painted houses, weathered cobblestones, and blooming window boxes, the car-free street near Bastille has become a popular destination to strike a pose, leaving residentsÃ¢â‚¬ doorways blocked by influencers and yoga aficionados alike. Now the people who live there have had enough. TheyÃ¢â‚¬re asking the city to put up a gate to keep visitors out on nights and weekends.
With #ruecremieux now linking to over 31,000 images, all the photobombing does sound wearisome. Ã¢â‚¬Å“We sit down to eat and just outside we have people taking photosÃ¢â‚¬â€�rappers who take two hours to film a video right beneath the window, or bachelorette parties who scream for an hour. Frankly, itÃ¢â‚¬s exhausting,Ã¢â‚¬ï¿½ one resident recently told radio station France Info. CityLabÃ¢â‚¬s Feargus OÃ¢â‚¬Sullivan has the story: The Special Curse of Living on InstagramÃ¢â‚¬s Favorite Street
What WeÃ¢â‚¬re Reading
Overlooked no more: Julia Morgan, pioneering female architect (New York Times)
What a fortune cookie factory tells us about San Francisco rent (BBC News)
If the worldÃ¢â‚¬s nighttime lights were mountains (Washington Post)
Your landlord turns your apartment into a smart home. Now what? (CNET)
Opinion: Cars are killing us. Within 10 years, we must phase them out. (The Guardian)